ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
Open Access
- 18 February 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in EMBO Molecular Medicine
- Vol. 3 (3), 167-180
- https://doi.org/10.1002/emmm.201100122
Abstract
The telomeric amplicon at 8p12 is common in oestrogen receptor‐positive (ER+) breast cancers. Array‐CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification was shown to correlate with increased gene and protein expression and was associated with a distinct expression signature and poor clinical outcome. ZNF703 transformed NIH 3T3 fibroblasts, behaving as a classical oncogene, and regulated proliferation in human luminal breast cancer cell lines and immortalized human mammary epithelial cells. Manipulation of ZNF703 expression in the luminal MCF7 cell line modified the effects of TGFβ on proliferation. Overexpression of ZNF703 in normal human breast epithelial cells enhanced the frequency of in vitro colony‐forming cells from luminal progenitors. Taken together, these data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer.This publication has 34 references indexed in Scilit:
- ZNF703 gene amplification at 8p12 specifies luminal B breast cancerEMBO Molecular Medicine, 2011
- Zeppo1 is a novel metastasis promoter that repressesE-cadherinexpression and regulates p120-catenin isoform expression and localizationGenes & Development, 2011
- ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactionsMethods, 2009
- Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesisOncogene, 2009
- Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closureProceedings of the National Academy of Sciences of the United States of America, 2009
- Nlz1/Znf703 acts as a repressor of transcriptionBMC Developmental Biology, 2008
- Lentiviral Transduction of Mammary Stem Cells for Analysis of Gene Function during Development and CancerCell Stem Cell, 2008
- Genomic and transcriptional aberrations linked to breast cancer pathophysiologiesCancer Cell, 2006
- A 1 Mb minimal amplicon at 8p11–12 in breast cancer identifies new candidate oncogenesOncogene, 2005
- Repeated observation of breast tumor subtypes in independent gene expression data setsProceedings of the National Academy of Sciences of the United States of America, 2003