IP 3 Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism
- 30 September 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5744), 2232-2234
- https://doi.org/10.1126/science.1114110
Abstract
Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP 3 R2 and IP 3 R3) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3 R2 and IP 3 R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP 3 R2 and IP 3 R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.Keywords
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