Asymmetric organocatalytic reductions mediated by dihydropyridines
Open Access
- 11 September 2007
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 5 (21), 3407-3417
- https://doi.org/10.1039/b711499k
Abstract
Catalytic asymmetric reduction reactions have long been the preserve of the transition metal catalyst. Inspired by the myriad efficient enzyme-catalysed reduction reactions routine in biological systems, chemists have recently begun to design chiral metal-free organocatalysts that employ synthetic dihydropyridine NADH analogues as the hydride source with impressive results. Recent developments in this burgeoning field are discussed.Keywords
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