Assessment of a Hotel-Based COVID-19 Isolation and Quarantine Strategy for Persons Experiencing Homelessness

Abstract
Isolation of individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and quarantine of close contacts are key public health interventions to limit the population-level spread of infection.1-3 However, individuals with coronavirus disease 2019 (COVID-19) who are homeless, unstably housed, or living in congregate settings or dense households face key structural barriers to isolation.4 With an estimated 568 000 people experiencing homelessness each night in the United States5 and numerous outbreaks of COVID-19 in homeless shelters,6,7 there is a pressing need for noncongregate solutions to support isolation of individuals in this population with COVID-19.