Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
Open Access
- 10 April 2006
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 203 (4), 809-812
- https://doi.org/10.1084/jem.20060522
Abstract
In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models.Keywords
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