Silica encapsulated manganese perovskite nanoparticles for magnetically induced hyperthermia without the risk of overheating
- 17 June 2009
- journal article
- Published by IOP Publishing in Nanotechnology
- Vol. 20 (27), 275610
- https://doi.org/10.1088/0957-4484/20/27/275610
Abstract
Nanoparticles of manganese perovskite of the composition La(0.75)Sr(0.25)MnO(3) uniformly coated with silica were prepared by encapsulation of the magnetic cores (mean crystallite size 24 nm) using tetraethoxysilane followed by fractionation. The resulting hybrid particles form a stable suspension in an aqueous environment at physiological pH and possess a narrow hydrodynamic size distribution. Both calorimetric heating experiments and direct measurements of hysteresis loops in the alternating field revealed high specific power losses, further enhanced by the encapsulation procedure in the case of the coated particles. The corresponding results are discussed on the basis of complex characterization of the particles and especially detailed magnetic measurements. Moreover, the Curie temperature (335 K) of the selected magnetic cores resolves the risk of local overheating during hyperthermia treatment.Keywords
This publication has 18 references indexed in Scilit:
- Magnetic Nanoparticles for Cancer TherapyCurrent Nanoscience, 2008
- Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and ApplicationAngewandte Chemie-International Edition, 2007
- Magnetic Nanoparticles and Their Applications in MedicineNanomedicine, 2006
- Magnetic nanoparticle design for medical applicationsProgress in Solid State Chemistry, 2006
- Towards breast cancer treatment by magnetic heatingJournal of Magnetism and Magnetic Materials, 2005
- Magnetic nanoparticles for selective heating of magnetically labelled cells in culture: preliminary investigationNanotechnology, 2004
- Applications of magnetic nanoparticles in biomedicineJournal of Physics D: Applied Physics, 2003
- Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermiaJournal of Magnetism and Magnetic Materials, 2001
- Hyperthermia in oncologyInternational Journal of Hyperthermia, 2001
- Selective Inductive Heating of Lymph NodesAnnals of Surgery, 1957