Hypoperfusion and T1-hypointense lesions in white matter in multiple sclerosis
- 8 July 2013
- journal article
- research article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 20 (3), 365-373
- https://doi.org/10.1177/1352458513495936
Abstract
Background: Longitudinal magnetic resonance imaging (MRI) studies show that a fraction of the multiple sclerosis (MS) T2-lesions contain T1-hypointense components that may persist to represent severe, irreversible tissue damage. It is not known why certain lesions convert to persistent T1-hypointense lesions. Objective: We hypothesized that the T1-hypointense lesions disproportionately distribute in the more hypoperfused areas of the brain. Here we investigated the association between hypoperfusion and T1-hypointense lesion distributions. Methods: MRI and cerebral blood flow (CBF) data were acquired on 45 multiple sclerosis (MS) patients and 20 healthy controls. CBF maps were generated using pseudo-continuous arterial spin labeling technique. The lesion probability distribution maps were superimposed on the CBF maps. Results: Two distinct CBF clusters were observed in the white matter (WM) both in healthy controls and MS patients. An overall reduction in CBF was observed in MS patients compared to healthy controls. The majority of the T1-hypointense lesions were concentrated almost exclusively in the WM regions with lower CBF. The T2-hyperintense lesions were more generally distributed in both higher and lower perfused WM. Conclusion: This study suggests an association between hypoperfusion and T1-hypointense lesions.Keywords
This publication has 43 references indexed in Scilit:
- Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple SclerosisJournal of Neuroscience, 2011
- Mitochondrial DNA deletions and neurodegeneration in multiple sclerosisAnnals of Neurology, 2010
- Estimation of labeling efficiency in pseudocontinuous arterial spin labelingMagnetic Resonance in Medicine, 2010
- Black holes in multiple sclerosis: definition, evolution, and clinical correlationsActa Neurologica Scandinavica, 2009
- Is multiple sclerosis a mitochondrial disease?Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Improved cerebellar tissue classification on magnetic resonance images of brainJournal of Magnetic Resonance Imaging, 2009
- Multiple sclerosisThe Lancet, 2008
- Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM templateNeuroImage, 2008
- Unified Approach for Multiple Sclerosis Lesion Segmentation on Brain MRIAnnals of Biomedical Engineering, 2006
- Cerebral White Matter Is Highly Vulnerable to IschemiaStroke, 1996