Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
- 24 October 2006
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 103 (43), 15975-15980
- https://doi.org/10.1073/pnas.0603883103
Abstract
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.This publication has 47 references indexed in Scilit:
- A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesisCytokine & Growth Factor Reviews, 2005
- Cloning an artificial gene encoding angiostatic anginex: From designed peptide to functional recombinant proteinBiochemical and Biophysical Research Communications, 2005
- In silico analysis of angiogenesis associated gene expression identifies angiogenic stage related profilesBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2005
- Altered primary afferent anatomy and reduced thermal sensitivity in mice lacking galectin-1Pain, 2005
- Galectins as modulators of tumour progressionNature Reviews Cancer, 2005
- Angiogenesis gene expression profiling in xenograft models to study cellular interactionsExperimental Cell Research, 2004
- The designer antiangiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal modelsThe FASEB Journal, 2002
- Apoptosis of T cells mediated by galectin-1Nature, 1995
- Galectins: A family of animal β-galactoside-binding lectinsCell, 1994
- The family of metazoan metal-independent β-galactoside-binding lectins: structure, function and molecular evolutionGlycobiology, 1993