Crystal structure of Mycobacterium tuberculosis 6-hydroxymethyl-7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action
- 6 October 2000
- journal article
- Published by Elsevier BV in Journal of Molecular Biology
- Vol. 302 (5), 1193-1212
- https://doi.org/10.1006/jmbi.2000.4094
Abstract
No abstract availableKeywords
This publication has 56 references indexed in Scilit:
- Dihydropteroate Synthase fromStreptococcus pneumoniae:Characterization of Substrate Binding Order and Sulfonamide InhibitionBiochemical and Biophysical Research Communications, 1999
- Structure and function of the dihydropteroate synthase from staphylococcus aureusJournal of Molecular Biology, 1997
- [20] Processing of X-ray diffraction data collected in oscillation modeMethods in Enzymology, 1997
- Improved Structure Refinement Through Maximum LikelihoodActa Crystallographica Section A Foundations of Crystallography, 1996
- In vitro susceptibility of clinical isolates of Mycobacterium avium and M. intracellulare to folate antagonistsDiagnostic Microbiology and Infectious Disease, 1994
- Free R value: a novel statistical quantity for assessing the accuracy of crystal structuresNature, 1992
- An efficient general-purpose least-squares refinement program for macromolecular structuresActa Crystallographica Section A Foundations of Crystallography, 1987
- Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical featuresPeptide Science, 1983
- Sulfonamide structure-activity relations in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analogJournal of Medicinal Chemistry, 1974
- The Enzymic Synthesis of Dihydropteroate and Dihydrofolate by Plasmodium bergheiThe Journal of Protozoology, 1973