Oral Administration of Ren-Shen-Yang-Rong-Tang ‘Ninjin’yoeito’ Protects against Hematotoxicity and Induces Immature Erythroid Progenitor Cells in 5-Fluorouracil-Induced Anemia
Open Access
- 1 January 2009
- journal article
- website
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 6 (2), 247-256
- https://doi.org/10.1093/ecam/nem080
Abstract
The purpose of this study was to investigate the efficacy of four different Japanese and Chinese herbal prescriptions, Ren-Shen-Yang-Rong-Tang (Ninjin’yoeito, NYT), Chai-Hu-Gui-Zhi-Gan-Jiang-Tang (Saikokeishikankyoto, SKKT), Si-Jun-Zi-Tang (Shikunshito, SKT) and Si-Wu-Tang (Shimotsuto, SMT), which are traditionally used for anemia and fatigue, against hematotoxicity in mice treated with 5-fluorouracil (5-FU). NYT 1–100 mg kg–1day–1injected orally for 7 consecutive days before and after 5-FU injection significantly suppressed reductions in red blood cell, white blood cell and platelet counts in peripheral blood, and accelerated their recovery. Administration of SKKT also produced a slight but significant improvement in 5-FU-induced erythrocytopenia, whereas SMT and SKT could not prevent anemia. Oral injection of NYT also inhibited 5-FU-induced decreases in peripheral reticulocyte and bone marrow cell counts on day 10, and markedly hastened their recovery on day 20, in a dose-dependent manner. Erythroid progenitor colonies, such as colony forming units-erythroid and burst forming units-erythroid, formed by marrow cells from mice treated with 5-FU were significantly increased by oral administration of NYT. These findings suggest that NYT has the potential to protect against hematotoxicity, and also has hematopoietic activity, through stimulation of immature erythroid progenitor cell differentiation.Keywords
This publication has 34 references indexed in Scilit:
- Water-soluble extracts from Angelica acutiloba Kitagawa enhance hematopoiesis by activating immature erythroid cells in mice with 5-fluorouracil-induced anemiaExperimental Hematology, 2004
- Protective effect of (+)-catechin against 5-fluorouracil-induced myelosuppression in miceToxicology, 2004
- Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: Effects on survival, metabolism, and functionCancer, 2004
- Combination Effects of Herbs in a Multi-herbal Formula: Expression of Juzen-taiho-to's Immuno-modulatory Activity on the Intestinal Immune SystemEvidence-Based Complementary and Alternative Medicine, 2004
- Isolation of (+)-Catechin and (-)-Epicatechin fromActinidia argutaas Bone Marrow Cell Proliferation Promoting CompoundsPlanta Medica, 2003
- Influence of the joint treatment with granulocyte colony‐stimulating factor and drugs elevating extracellular adenosineon erythropoietic recovery following 5‐fluorouracil‐induced haematotoxicityin miceEuropean Journal of Haematology, 2000
- Recipient-mediated effect of a traditional chinese herbal medicine, Ren-shen-yang-rong-tang (Japanese name: Ninjin-youei-to), on hematopoietic recovery following lethal irradiation and syngeneic bone marrow transplantationInternational Journal of Immunopharmacology, 1994
- Protective effect of ren-shen-yang-rong-tang (Ninjin-Youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infectionInternational Journal of Immunopharmacology, 1992
- Inhibition of human erythroid colony‐forming units by interleukin‐1 is mediated by gamma interferonJournal of Cellular Physiology, 1992
- The Human Hematopoietic Colony-Stimulating FactorsScience, 1987