The use of dermal substitutes in burn surgery: Acute phase
- 6 January 2014
- journal article
- research article
- Published by Wiley in Wound Repair and Regeneration
- Vol. 22 (1), 14-22
- https://doi.org/10.1111/wrr.12119
Abstract
Major burns represent a challenge in autologous skin coverage and may lead to severe functional and cosmetic sequelae. Dermal substitutes are increasingly becoming an essential part of burn care during the acute phase of treatment. In the long term dermal substitutes improve functional and cosmetic results and thus enhance quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and defects. Despite the potential of dermal substitutes, further research is required to strengthen scientific evidence regarding their effects and also to develop new technologies and products. Furthermore, dermal substitutes have a pivotal role in future research strategies as they have the potential to provide adequate scaffold for stem cells, tissue engineering, and regenerative medicine with conceivable application of obtaining long‐lasting and scarless artificial skin. This review discusses the status quo of dermal substitutes and novel strategies in the use of dermal substitutes with a focus on burn care.Keywords
This publication has 60 references indexed in Scilit:
- Stem Cell Therapy: A New Treatment for Burns?Pharmaceuticals, 2011
- New dermal substitutesWound Repair and Regeneration, 2011
- Severe Burn Injuries and the Role of Elastin in the Design of Dermal SubstitutesTissue Engineering, Part B: Reviews, 2011
- Reconstruction of the radial forearm free flap donor site using integra artificial dermisMicrosurgery, 2010
- Biological background of dermal substitutesBurns, 2010
- Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-UpPlastic and Reconstructive Surgery, 2010
- Synthetic scaffold morphology controls human dermal connective tissue formationJournal of Biomedical Materials Research Part A, 2005
- Xenografts are an achievable breakthroughMedical Hypotheses, 2004
- Cultured Skin Substitutes: A ReviewTissue Engineering, 1996
- Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burnsBurns, 1995