Music-induced cortical plasticity and lateral inhibition in the human auditory cortex as foundations for tonal tinnitus treatment
Open Access
- 1 January 2012
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Systems Neuroscience
- Vol. 6, 50
- https://doi.org/10.3389/fnsys.2012.00050
Abstract
Over the past 15 years, we have studied plasticity in the human auditory cortex by means of magnetoencephalography (MEG). Two main topics nurtured our curiosity: the effects of musical training on plasticity in the auditory system, and the effects of lateral inhibition. One of our plasticity studies found that listening to notched music for 3 h inhibited the neuronal activity in the auditory cortex that corresponded to the center-frequency of the notch, suggesting suppression of neural activity by lateral inhibition. Subsequent research on this topic found that suppression was notably dependent upon the notch width employed, that the lower notch-edge induced stronger attenuation of neural activity than the higher notch-edge, and that auditory focused attention strengthened the inhibitory networks. Crucially, the overall effects of lateral inhibition on human auditory cortical activity were stronger than the habituation effects. Based on these results we developed a novel treatment strategy for tonal tinnitus—tailor-made notched music training (TMNMT). By notching the music energy spectrum around the individual tinnitus frequency, we intended to attract lateral inhibition to auditory neurons involved in tinnitus perception. So far, the training strategy has been evaluated in two studies. The results of the initial long-term controlled study (12 months) supported the validity of the treatment concept: subjective tinnitus loudness and annoyance were significantly reduced after TMNMT but not when notching spared the tinnitus frequencies. Correspondingly, tinnitus-related auditory evoked fields (AEFs) were significantly reduced after training. The subsequent short-term (5 days) training study indicated that training was more effective in the case of tinnitus frequencies ≤ 8 kHz compared to tinnitus frequencies >8 kHz, and that training should be employed over a long-term in order to induce more persistent effects. Further development and evaluation of TMNMT therapy are planned. A goal is to transfer this novel, completely non-invasive and low-cost treatment approach for tonal tinnitus into routine clinical practice.Keywords
This publication has 105 references indexed in Scilit:
- Systematic review and meta‐analyses of randomized controlled trials examining tinnitus managementThe Laryngoscope, 2011
- Music Making as a Tool for Promoting Brain Plasticity across the Life SpanThe Neuroscientist, 2010
- Tuning Out the Noise: Limbic-Auditory Interactions in TinnitusNeuron, 2010
- Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activityProceedings of the National Academy of Sciences of the United States of America, 2009
- Frequency-specific modulation of population-level frequency tuning in human auditory cortexBMC Neuroscience, 2009
- Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear traumaJournal of Neuroscience Research, 2008
- Asymmetric lateral inhibitory neural activity in the auditory system: a magnetoencephalographic studyBMC Neuroscience, 2007
- Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputationNature, 1995
- Receptive field dynamics in adult primary visual cortexNature, 1992
- Reorganization of Retinotopic Cortical Maps in Adult Mammals After Lesions of the RetinaScience, 1990