The risks of selective serotonin reuptake inhibitor use in infertile women: a review of the impact on fertility, pregnancy, neonatal health and beyond
Open Access
- 31 October 2012
- journal article
- review article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 28 (1), 160-171
- https://doi.org/10.1093/humrep/des383
Abstract
What is the current literature on the safety and efficacy of selective serotonin reuptake inhibitor (SSRI) use in infertile women? There is little evidence that infertile women benefit from taking an SSRI, therefore they should be counseled appropriately about the risks and be advised to consider alternate safer treatments to treat depressive symptoms. SSRI use is associated with possible reduced infertility treatment efficacy as well as higher rates of pregnancy loss, preterm birth, pregnancy complications, neonatal issues and long-term neurobehavioral abnormalities in offspring. Review of existing literature. We conducted a review of all published studies that evaluate females with depressive symptoms who are taking antidepressant medications and who are experiencing infertility. Antidepressant use during pregnancy is associated with increased risks of miscarriage, birth defects, preterm birth, newborn behavioral syndrome, persistent pulmonary hypertension of the newborn and possible longer term neurobehavioral effects. There is no evidence of improved pregnancy outcomes with antidepressant use. There is some evidence that psychotherapy, including cognitive-behavioral therapy as well as physical exercise, is associated with significant decreases in depressive symptoms in the general population; research indicates that some forms of counseling are effective in treating depressive symptoms in infertile women. Our findings are limited by the availability of published studies in the field, which are often retrospective and of small size. Practitioners who care for infertility patients should have a thorough understanding of the published literature so that they can adequately counsel their patients. None.Keywords
This publication has 89 references indexed in Scilit:
- Does Antidepressant Use Attenuate the Risk of a Major Depressive Episode in Pregnancy?Epidemiology, 2011
- Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trialBrain, Behavior, and Immunity, 2011
- Acupuncture for Depression: A Critique of the Evidence BaseCNS Neuroscience & Therapeutics, 2010
- Antidepressant Use During Pregnancy and the Risk of Preterm Delivery and Fetal Growth RestrictionJournal of Clinical Psychopharmacology, 2009
- The Management of Depression During Pregnancy: A Report from the American Psychiatric Association and the American College of Obstetricians and GynecologistsObstetrics & Gynecology, 2009
- Selective Serotonin Reuptake Inhibitor Use and Risk of Gestational HypertensionAmerican Journal of Psychiatry, 2009
- Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatmentHuman Reproduction, 2008
- Selective Publication of Antidepressant Trials and Its Influence on Apparent EfficacyNew England Journal of Medicine, 2008
- Yoga as a Complementary Treatment of Depression: Effects of Traits and Moods on Treatment OutcomeEvidence-Based Complementary and Alternative Medicine, 2007
- Do Antidepressants Cure or Create Abnormal Brain States?PLoS Medicine, 2006