Sleep disorders are long-term sequelae of both bacterial and viral meningitis
Open Access
- 1 April 2006
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 77 (4), 554-558
- https://doi.org/10.1136/jnnp.2005.071142
Abstract
Background: Many bacterial meningitis patients experience neurological or neuropsychological sequelae, predominantly deficits in short-term memory, learning, and attention. Neuropsychological symptoms after viral meningitis are observed less frequently. Sleep disturbance has been reported after both viral and bacterial meningitis. Objectives: To examine systematically the frequency and extent of sleep disturbance in meningitis patients. Methods: Eighty six viral or bacterial meningitis (onset of acute disease at least 1 year previously) patients were examined using two standardised questionnaires (Schlaffragebogen B and the Pittsburgh Sleep Quality Index, PSQI) in conjunction with a standardised neurological examination, and compared to a control group of 42 healthy age-matched volunteers. Results: Patients after both viral and bacterial meningitis described their sleep as reduced in quality and less restful than that of healthy control subjects; both patient groups had a pathological mean PSQI total score. Impaired sleep scores after meningitis were not correlated to either the Glasgow Coma Scale or the Glasgow Outcome Scale. Moreover, no relationship between residual neurological dysfunction or depressivity and sleep quality was observed. Conclusions: Impaired sleep is a long-term consequence of meningitis. Additional, so far undetermined, factors other than the severity of concomitant neurological deficits are responsible for the development of this sequela.Keywords
This publication has 42 references indexed in Scilit:
- Metabolites of the Kynurenine Pathway of Tryptophan Metabolism in the Cerebrospinal Fluid of Malawian Children with MalariaThe Journal of Infectious Diseases, 2003
- Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis*Critical Care Medicine, 2002
- Sleep and quality of life in the Austrian populationActa Neurologica Scandinavica, 2000
- Prognosis of bacterial meningitis in childrenArquivos de Neuro-Psiquiatria, 1996
- Chronic fatigue and minor psychiatric morbidity after viral meningitis: a controlled study.Journal of Neurology, Neurosurgery & Psychiatry, 1996
- Fatigue in MS is associated with specific clinical featuresActa Neurologica Scandinavica, 1995
- Impairment of respiratory rhythmogenesis and sequelae of bacterial meningitisPediatric Neurology, 1995
- Daytime sleep in myotonic dystrophy is not caused by sleep apnoea.Journal of Neurology, Neurosurgery & Psychiatry, 1994
- QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASEBrain, 1992
- Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivativeInternational Journal of Immunopharmacology, 1989