Long-lasting desynchronization in rat hippocampal slice induced by coordinated reset stimulation
- 2 July 2009
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 80 (1), 011902
- https://doi.org/10.1103/physreve.80.011902
Abstract
In computational models it has been shown that appropriate stimulation protocols may reshape the connectivity pattern of neural or oscillator networks with synaptic plasticity in a way that the network learns or unlearns strong synchronization. The underlying mechanism is that a network is shifted from one attractor to another, so that long-lasting stimulation effects are caused which persist after the cessation of stimulation. Here we study long-lasting effects of multisite electrical stimulation in a rat hippocampal slice rendered epileptic by magnesium withdrawal. We show that desynchronizing coordinated reset stimulation causes a long-lasting desynchronization between hippocampal neuronal populations together with a widespread decrease in the amplitude of the epileptiform activity. In contrast, periodic stimulation induces a long-lasting increase in both synchronization and amplitude.Keywords
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