Circadian rhythm of intraocular pressure in cats
- 13 April 2007
- journal article
- research article
- Published by Wiley in Veterinary Ophthalmology
- Vol. 10 (3), 155-161
- https://doi.org/10.1111/j.1463-5224.2007.00525.x
Abstract
To evaluate the rhythm of intraocular pressure (IOP) in healthy domestic cats with no evidence of ocular disease and to analyze the influence of photoperiod, age, gender and ocular diseases on diurnal-nocturnal variations of cat IOP. All animals were Domestic Short-haired cats; 30 were without systemic or ocular diseases, classified as follows: 12 male intact adult cats, five intact adult female, five adult spayed female, and eight male cats; the latter were less than 1 year of age. In addition, five adult cats with uveitis and three adult cats with secondary glaucoma were included. IOP was assessed with a Tono-Pen XL at 3-h intervals over a 24-h period in 12 healthy adult male cats kept under a photoperiod of 12-h light/12-h darkness for 2 weeks. Eight animals from the same group were then kept under constant darkness for 48 h, and IOP was measured at 3-h intervals for the following 24 h. In addition, IOP was assessed at 3 p.m. and 9 p.m. in five intact females, five spayed females, and in eight young cats, as well as in five adult cats with uveitis and three glaucomatous cats. Consistent, daily variations in IOP were observed in animals exposed to a light-dark cycle, with maximal values during the night. In cats exposed to constant darkness, maximal values of IOP were observed at subjective night. Differences of IOP values between 3 p.m. and 9 p.m. (diurnal-nocturnal variations) persisted in intact females, spayed females, and young animals, as well as in uveitic and glaucomatous eyes. The present results indicate a daily rhythm of cat IOP, which appears to persist in constant darkness, suggesting some level of endogenous circadian control. In addition, daily variations of cat IOP seem to be independent of gender, age, or ocular diseases (particularly uveitis and glaucoma).Keywords
This publication has 31 references indexed in Scilit:
- Ex vivo Evaluation of Tono-Pen and Pneumotonometry in Cat EyesOphthalmic Research, 2005
- Change in intraocular pressure during maturation in Labrador Retriever dogsVeterinary Ophthalmology, 2004
- AL-2512, a Novel Corticosteroid: Preclinical Assessment of Anti-Inflammatory and Ocular Hypertensive EffectsJournal of Ocular Pharmacology and Therapeutics, 2003
- The feline glaucomas: 82 cases (1995–1999)Veterinary Ophthalmology, 2001
- Changing therapeutic paradigms in glaucoma managementExpert Opinion on Investigational Drugs, 1998
- Circadian rhythm of intraocular pressure in the ratCurrent Eye Research, 1996
- Effects of excitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to retinohypothalamic tract volleysBrain Research, 1989
- Physiological Variables Affecting Intraocular Pressure in a Population StudyOptometry and Vision Science, 1988
- Daily fluctuations in the detectability of dim lights by humansPhysiology & Behavior, 1986
- INFLUENCE OF LIGHT ON THE 24‐HOUR VARIATION IN AQUEOUS FLARE DENSITY AND INTRA‐OCULAR PRESSURE IN NORMAL RABBITS' EYESActa Ophthalmologica, 1961