Oxidative stress and antioxidants: exposure and impact on female fertility
Top Cited Papers
Open Access
- 2 April 2008
- journal article
- review article
- Published by Oxford University Press (OUP) in Human Reproduction Update
- Vol. 14 (4), 345-357
- https://doi.org/10.1093/humupd/dmn011
Abstract
Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility and early pregnancy loss, a growing body of literature suggests that environmental and lifestyle factors play an important role. There is sufficient evidence to hypothesize that diet, particularly its constituent antioxidants, and oxidative stress (OS) may influence the timing and maintenance of a viable pregnancy. We hypothesize that conditions leading to OS in the female affect time-to-pregnancy and early pregnancy loss. We review the epidemiology of female infertility related to antioxidant defenses and oxidation and examine potential sources of OS from the ovarian germ cell through the stages of human pregnancy and pregnancy complications related to infertility. Articles were identified through a search of the PubMed database. Female OS is a likely mediator of conception and threshold levels for OS exist, dependent on anatomic location and stage of preconception. Prospective pregnancy studies with dietary assessment and collection of biological samples prior to conception with endpoints of time-to-pregnancy and early pregnancy loss are needed.Keywords
This publication has 100 references indexed in Scilit:
- Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1Biology of Reproduction, 1999
- The effect of preconceptional multivitamin supplementation on the menstrual cycleArchiv für Gynäkologie, 1995
- Effects of Smoking on the Levels of Antioxidant Beta Carotene, Alpha Tocopherol and Retinol in Human Ovarian Follicular FluidGynecologic and Obstetric Investigation, 1995
- Physical Activity, Nutrition, and ReproductionAnnals of the New York Academy of Sciences, 1994
- Oxidative Stress during the Interaction of Gametes1Biology of Reproduction, 1993
- NADPH-diaphorase-positive nerves and the role of nitric oxide in CGRP relaxation of uterine contractionPeptides, 1993
- CAFFEINATED BEVERAGES AND DECREASED FERTILITYThe Lancet, 1989
- Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study.BMJ, 1985
- Free radicals and tissue damage produced by exerciseBiochemical and Biophysical Research Communications, 1982
- DECIDUAL ALKALINE PHOSPHATASE ACTIVITY IN THE PREGNANT AND PSEUDOPREGNANT RATAnnals of the New York Academy of Sciences, 1969