The current edition of Tropical Infectious Diseases: Principles, Pathogens, and Practice is the second edition of this outstanding textbook, which was originally published in 1999 and has become one of the essential resources for this extensive area of medicine. The textbook is in 2 volumes, comprising 3 sections: “Principles and General Considerations,” “Pathogens,” and “Practice: Approach to the Patient in the Tropics.” Volume 1 comprises section I and a large component of section II (covering bacterial and viral infections). Volume 2 covers fungal and parasitic infections. This review covers only volume 1. The 2 volumes are well laid out, with a generous number of illustrations and tables to complement the text. The majority of illustrations are in black and white, probably for reasons of cost, although there are 8 pages of color plates at the start of the volume that display venomous reptiles, arthropods, marine animals, and various clinical conditions that are best suited to color reproduction. A CD-ROM is included with the book that contains all of the text and figures in a portable document file (pdf) format that is accessible via a searchable browser interface in both PC and Mac formats. The editors have successfully achieved a consistently high quality throughout this multiple-author text, which has a list of contributors that reads like a who's who of the tropical medicine world.