Functions of AMP‐activated protein kinase in adipose tissue
- 19 June 2006
- journal article
- review article
- Published by Wiley in The Journal of Physiology
- Vol. 574 (1), 55-62
- https://doi.org/10.1113/jphysiol.2006.111484
Abstract
AMP-activated protein kinase (AMPK) is involved in cellular energy homeostasis. Its functions have been extensively studied in muscles and liver. AMPK stimulates pathways which increase energy production (glucose transport, fatty acid oxidation) and switches off pathways which consume energy (lipogenesis, protein synthesis, gluconeogenesis). This has led to the concept that AMPK has an interesting pharmaceutical potential in situations of insulin resistance and it is indeed the target of existing drugs and hormones which improve insulin sensitivity. Adipose tissue is a key player in energy metabolism through the release of substrates and hormones involved in metabolism and insulin sensitivity. Activation of AMPK in adipose tissue can be achieved through situations such as fasting and exercise. Leptin and adiponectin as well as hypoglycaemic drugs are activators of adipose tissue AMPK. This activation probably involves changes in the AMP/ATP ratio and the upstream kinase LKB1. When activated, AMPK limits fatty acid efflux from adipocytes and favours local fatty acid oxidation. Since fatty acids have a key role in insulin resistance, especially in muscles, activating AMPK in adipose tissue might be found to be beneficial in insulin-resistant states, particularly as AMPK activation also reduces cytokine secretion in adipocytes.Keywords
This publication has 71 references indexed in Scilit:
- Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazoneBiochemical and Biophysical Research Communications, 2006
- AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytesBiochemical and Biophysical Research Communications, 2005
- AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exerciseBiochemical and Biophysical Research Communications, 2004
- Possible involvement of AMP‐activated protein kinase in obesity resistance induced by respiratory uncoupling in white fatFEBS Letters, 2004
- AICAR stimulates adiponectin and inhibits cytokines in adipose tissueBiochemical and Biophysical Research Communications, 2004
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseNature, 2002
- Role of AMP-activated protein kinase in mechanism of metformin actionJCI Insight, 2001
- The Effects of AICAR on Adipocyte Differentiation of 3T3-L1 CellsBiochemical and Biophysical Research Communications, 2001
- Mammalian AMP-activated Protein Kinase SubfamilyJournal of Biological Chemistry, 1996
- Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinaseFEBS Letters, 1994