Synthesis of Perspicamide A and Related Diverse Analogues: Their Bioevaluation as Potent Antileishmanial Agents
- 4 January 2013
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 78 (4), 1534-1546
- https://doi.org/10.1021/jo3025626
Abstract
The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 24b, 24c, 24d, and 24l, exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 μM and a selectivity index (SI) ranging from 9.58 to 53.12, which is improved compared to the standard drug Miltefosine (IC50 12.4 μM and SI 4.1).Keywords
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