The Role of PPARActivation in Liver and Muscle
Open Access
- 1 January 2010
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2010, 1-11
- https://doi.org/10.1155/2010/542359
Abstract
PPARis one of three members of the soluble nuclear receptor family called peroxisome proliferator-activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and their derivatives that responds to ligand binding with PPAR target gene transcription, inasmuch as it can influence physiological homeostasis, including lipid and carbohydrate metabolism in various tissues. In this paper we summarize the involvement of PPARin the metabolically active tissues liver and skeletal muscle and provide an overview of the risks and benefits of ligand activation of PPAR, with particular consideration to interspecies differences.
Funding Information
- NordForsk (070010)
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