Allergen‐induced increase in non‐allergic bronchial reactivity
- 1 November 1977
- journal article
- research article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 7 (6), 503-513
- https://doi.org/10.1111/j.1365-2222.1977.tb01481.x
Abstract
Non-allergic bronchial hyper-reactivity is a feature of most patients with asthma. We have measured non-allergic bronchial reactivity to inhaled histamine and methacholine in thirteen asthmatic subjects before and after allergen inhalation in the laboratory. The allergen inhalation produced mild early asthmatic responses (19–40% FEV1 fall) in all thirteen, additional definite late asthmatic responses (17–29% FEV1 fall) in four, and equivocal late asthmatic responses (5–11% FEV1 fall) in five. Following allergen inhalation, non-allergic bronchial reactivity increased in seven for up to 7 days. The seven included all four with definite late asthmatic responses and three of the five with equivocal late asthmatic responses. We conclude that allergens make asthma worse, partly through non-allergic mechanisms, and that avoidance of allergens is important in reducing non-allergic bronchial hyper-reactivity.This publication has 15 references indexed in Scilit:
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