[(S)-γ-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
- 1 June 2006
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry
- Vol. 14 (11), 3662-3671
- https://doi.org/10.1016/j.bmc.2006.01.022
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- 1-((S)-γ-Substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitorsBioorganic & Medicinal Chemistry Letters, 2005
- Dipeptidyl Peptidase IV Inhibitors for the Treatment of DiabetesJournal of Medicinal Chemistry, 2004
- VildagliptinDrugs of the Future, 2004
- Design, Synthesis, and SAR of Potent and Selective Dipeptide-Derived Inhibitors for Dipeptidyl PeptidasesJournal of Medicinal Chemistry, 2003
- 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic PropertiesJournal of Medicinal Chemistry, 2003
- Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker RatsDiabetes, 2002
- Chapter 19. DPP-IV inhibition and therapeutic potentialPublished by Elsevier BV ,2001
- P32/98Drugs of the Future, 2001
- Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivoJournal of Clinical Endocrinology & Metabolism, 1995
- Mechanism of proline-specific proteinases: (I) substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticumBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1988