PTH(1-84) replacement therapy for the treatment of hypoparathyroidism
- 14 September 2014
- journal article
- Published by Taylor & Francis Ltd in Expert Review of Endocrinology & Metabolism
- Vol. 10 (1), 5-13
- https://doi.org/10.1586/17446651.2015.971755
Abstract
Hypoparathyroidism is a rare disease characterized by hypocalcemia and insufficient circulating levels of parathyroid hormone (PTH). Conventional therapy includes calcium and active vitamin D supplementation, often in large doses. Therapy with calcium and vitamin D, however, does not address certain problematic aspects of the disease, including abnormal bone metabolism and reduced quality of life. Hypoparathyroidism is the only classic endocrine deficiency disease for which the missing hormone, PTH, is not yet an approved treatment. PTH(1-84) may soon become a therapeutic option for patients with hypoparathyroidism. PTH(1-84) has been demonstrated to maintain serum calcium while reducing or eliminating requirements for calcium and active vitamin D supplementation. Data from bone densitometry, bone turnover markers and histomorphometry of bone biopsy specimens show positive structural and dynamic effects on the skeleton. PTH replacement therapy may also be associated with improved quality of life. PTH(1-84) replacement therapy for hypoparathyroidism is promising, although further acquisition of long-term data is needed.Keywords
This publication has 54 references indexed in Scilit:
- CorrigendaJournal of Clinical Endocrinology & Metabolism, 2015
- Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral densityBMC Endocrine Disorders, 2013
- The US postmarketing surveillance study of adult osteosarcoma and teriparatide: Study design and findings from the first 7 yearsJournal of Bone and Mineral Research, 2012
- Mini-review: new therapeutic options in hypoparathyroidismEndocrine, 2012
- Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future researchJournal of Bone and Mineral Research, 2011
- Long-Term Treatment of 12 Children with Chronic Hypoparathyroidism: A Randomized Trial Comparing Synthetic Human Parathyroid Hormone 1-34 versus Calcitriol and CalciumJournal of Clinical Endocrinology & Metabolism, 2010
- Three dimensional cancellous bone structure in hypoparathyroidismBone, 2010
- Therapy of hypoparathyroidism with intact parathyroid hormoneOsteoporosis International, 2010
- Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidismBone, 2007
- The MOS 36-ltem Short-Form Health Survey (SF-36)Medical Care, 1992