Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma
- 10 September 2015
- journal article
- case report
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 373 (11), 1040-1047
- https://doi.org/10.1056/nejmoa1504542
Abstract
A patient with refractory multiple myeloma received an infusion of CTL019 cells, a cellular therapy consisting of autologous T cells transduced with an anti-CD19 chimeric antigen receptor, after myeloablative chemotherapy (melphalan, 140 mg per square meter of body-surface area) and autologous stem-cell transplantation. Four years earlier, autologous transplantation with a higher melphalan dose (200 mg per square meter) had induced only a partial, transient response. Autologous transplantation followed by treatment with CTL019 cells led to a complete response with no evidence of progression and no measurable serum or urine monoclonal protein at the most recent evaluation, 12 months after treatment. This response was achieved despite the absence of CD19 expression in 99.95% of the patient’s neoplastic plasma cells. (Funded by Novartis and others; ClinicalTrials.gov number, NCT02135406.)Keywords
This publication has 19 references indexed in Scilit:
- Current concepts in the diagnosis and management of cytokine release syndromeBlood, 2014
- B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous CarcinomasCancer Cell, 2014
- Flow cytometric differentiation of abnormal and normal plasma cells in the bone marrow in patients with multiple myeloma and its precursor diseasesLeukemia Research, 2013
- Myeloma stem cell concepts, heterogeneity and plasticity of multiple myelomaBritish Journal of Haematology, 2013
- Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple MyelomaCancer Cell, 2013
- Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid LeukemiaThe New England Journal of Medicine, 2013
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid LeukemiaThe New England Journal of Medicine, 2011
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced LeukemiaScience Translational Medicine, 2011
- Transfer of influenza vaccine–primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trialBlood, 2011
- Bone marrow stromal cell interaction reduces Syndecan-1 expression and induces kinomic changes in myeloma cellsExperimental Cell Research, 2010