Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism
- 27 December 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4170), 1213-1215
- https://doi.org/10.1126/science.186.4170.1213
Abstract
In male pseudohermaphrodites born with ambiguity of the external genitalia but with marked virilization at puberty, biochemical evaluation reveals a marked decrease in plasma dihydrotestosterone secondary to a decrease in steroid 5alpha-reductase activity. In utero the decrease in dihydrotestosterone results in incomplete masculinization of the external genitalia. Inheritance is autosomal recessive.Keywords
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