The Emergence of the Randomized, Controlled Trial
- 11 August 2016
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 375 (6), 501-504
- https://doi.org/10.1056/nejmp1604635
Abstract
The birth of the randomized, controlled trial (RCT) is typically dated to a 1948 evaluation by the British Medical Research Council (MRC) of streptomycin for the treatment of tuberculosis. But controlled clinical trials and discussions of their designs were increasingly being published in medical journals for at least half a century before the MRC’s report, which was part of a much longer history of efforts to empirically assess experimental therapies. An exploration of this deeper history offers insights into the intellectual and social forces shaping both the advent of and resistance to the controlled clinical trial as a medical research standard and mechanism for taming the therapeutic marketplace.This publication has 2 references indexed in Scilit:
- From Trials to TrialsPublished by Elsevier BV ,2016
- The advent of fair treatment allocation schedules in clinical trials during the 19th and early 20th centuriesJournal of the Royal Society of Medicine, 2012