Areas of Nonperfusion in Peripheral Retina of Eyes With Pathologic Myopia Detected by Ultra-Widefield Fluorescein Angiography
- 1 March 2014
- journal article
- retina
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 55 (3), 1432-1439
- https://doi.org/10.1167/iovs.13-13706
Abstract
Purpose.: We investigated the vascular system in the far peripheral retina in eyes with pathologic myopia by ultra-widefield fluorescein angiography (FA). Methods.: We analyzed retrospectively 230 with pathologic myopia (myopic refractive error >8 diopters [D] or axial length >26.5 mm) and 42 emmetropic (refractive error < ±2 D) controls who were examined with ultra-widefield FA by the Optos P200 system. Far peripheral retina was defined as the area anterior to the ampullae of the vortex veins. Results.: Retinal capillary telangiectasia was observed in the far periphery of 34 of 42 (81.0%) emmetropic eyes and in 90 of 115 (78.3%) highly myopic eyes. Retinal capillary microaneurysms were observed in 13 of 42 (31.0%) emmetropic eyes and in 60 of 115 (52.2%) eyes with pathologic myopia. The differences in the incidences of these two lesions were not significant. Areas of nonperfusion in the far periphery were found in two of 42 (4.8%) emmetropic eyes and in 95 of 115 (82.6%) eyes with pathologic myopia. In these myopic eyes, the arterioles and venules had an abrupt ending, and in advanced cases, the perfused area was limited to just beyond the staphyloma border. None of the eyes developed retinal neovascularization. Statistical analyses showed that the highly myopic patients with avascular areas in the far periphery were significantly older, and had significantly longer axial length. Conclusions.: Areas of nonperfusion in the far periphery are common in eyes with pathologic myopia. Retinal vasculature in the far periphery is significantly altered in eyes with pathologic myopia, and this may be due to a mechanical stretching.Keywords
This publication has 18 references indexed in Scilit:
- Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitisJournal of Ophthalmic Inflammation and Infection, 2013
- PROSPECTIVE STUDY OF PERIPHERAL PANRETINAL PHOTOCOAGULATION OF AREAS OF NONPERFUSION IN CENTRAL RETINAL VEIN OCCLUSIONRetina, 2013
- Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their ShapesInvestigative Opthalmology & Visual Science, 2012
- ULTRA–WIDE-FIELD ANGIOGRAPHY IMPROVES THE DETECTION AND CLASSIFICATION OF DIABETIC RETINOPATHYRetina, 2012
- Topographic Analyses of Shape of Eyes with Pathologic Myopia by High-Resolution Three-Dimensional Magnetic Resonance ImagingOphthalmology, 2011
- PERIPHERAL AREAS OF NONPERFUSION IN TREATED CENTRAL RETINAL VEIN OCCLUSION AS IMAGED BY WIDE-FIELD FLUORESCEIN ANGIOGRAPHYRetina, 2011
- DETECTION AND MONITORING OF SICKLE CELL RETINOPATHY USING ULTRA WIDE-FIELD COLOR PHOTOGRAPHY AND FLUORESCEIN ANGIOGRAPHYRetina, 2011
- Ultra-Wide-Field Fluorescein Angiography of the Ocular FundusAmerican Journal of Ophthalmology, 2005
- Prevalence and progression of myopic retinopathy in an older populationOphthalmology, 2002
- Complications associated with posterior staphylomaCurrent Opinion in Opthalmology, 1998