Depressive symptoms and risk of liver-related mortality in individuals with hepatitis B virus infection: a cohort study
Open Access
- 30 November 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 10 (1), 1-10
- https://doi.org/10.1038/s41598-020-77886-2
Abstract
The impact of depression on the risk of liver-related mortality in individuals with hepatitis B virus (HBV) infection remains unclear. We examined the association between depression, HBV infection, and liver-related mortality. A total of 342,998 Korean adults who underwent health examinations were followed for up to 7.8 years. Depressive symptoms were defined as a Center for Epidemiologic Studies-Depression score ≥ 16. Cox proportional hazard models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). During 1,836,508 person-years of follow-up, 74 liver-related deaths and 54 liver cancer deaths were identified (liver-related mortality rate of 4.0 per 105 person-years and liver cancer mortality rate of 2.9 per 105 person-years). Subjects with depressive symptoms had an increased risk of liver-related mortality with a corresponding multivariable aHR of 2.00 (95% CI 1.10–3.63) compared to those without depressive symptoms. This association was more evident in HBsAg-positive participants with a corresponding multivariable aHR of 4.22 (95% CI 1.81–9.88) than HBsAg-negative participants (P for interaction by HBsAg positivity = 0.036). A similar pattern was observed in relation to liver cancer mortality. In this large cohort, depressive symptoms were associated with an increased risk of liver-related mortality, with a stronger association in HBsAg-positive individuals.This publication has 61 references indexed in Scilit:
- Metabolic Syndrome and Risk of CancerDiabetes Care, 2012
- Bidirectional Association Between Depression and Metabolic SyndromeDiabetes Care, 2012
- Validity and Reliability of Korean Version of International Physical Activity Questionnaire Short Form in the ElderlyKorean Journal of Family Medicine, 2012
- Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver DiseaseClinical Gastroenterology and Hepatology, 2009
- Depressive Symptoms, Health Behaviors, and Risk of Cardiovascular Events in Patients With Coronary Heart DiseaseJAMA, 2008
- Suspected Nonalcoholic Fatty Liver Disease and Mortality Risk in a Population-Based Cohort StudyThe American Journal of Gastroenterology, 2008
- More Claims About Depression, Immune Function, and Survival That Exceed the EvidenceJournal of Clinical Oncology, 2007
- Immunology of hepatitis B virus and hepatitis C virus infectionNature Reviews Immunology, 2005
- Psychological interventions and the immune system: A meta-analytic review and critique.Health Psychology, 2001
- Psychological interventions and the immune system: A meta-analytic review and critique.Health Psychology, 2001