Inorganic Arsenic and Human Prostate Cancer
Open Access
- 1 February 2008
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 116 (2), 158-164
- https://doi.org/10.1289/ehp.10423
Abstract
We critically evaluated the etiologic role of inorganic arsenic in human prostate cancer. We assessed data from relevant epidemiologic studies concerning environmental inorganic arsenic exposure. Whole animal studies were evaluated as were in vitro model systems of inorganic arsenic carcinogenesis in the prostate. Multiple studies in humans reveal an association between environmental inorganic arsenic exposure and prostate cancer mortality or incidence. Many of these human studies provide clear evidence of a dose–response relationship. Relevant whole animal models showing a relationship between inorganic arsenic and prostate cancer are not available. However, cellular model systems indicate arsenic can induce malignant transformation of human prostate epithelial cells in vitro. Arsenic also appears to impact prostate cancer cell progression by precipitating events leading to androgen independence in vitro. Available evidence in human populations and human cells in vitro indicates that the prostate is a target for inorganic arsenic carcinogenesis. A role for this common environmental contaminant in human prostate cancer initiation and/or progression would be very important.Keywords
This publication has 73 references indexed in Scilit:
- Interplay between Cellular Methyl Metabolism and Adaptive Efflux during Oncogenic Transformation from Chronic Arsenic Exposure in Human CellsPublished by Elsevier BV ,2008
- Transplacental arsenic carcinogenesis in miceToxicology and Applied Pharmacology, 2007
- Mechanisms of Acquired Androgen Independence during Arsenic-Induced Malignant Transformation of Human Prostate Epithelial CellsEnvironmental Health Perspectives, 2007
- Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistanceAdvances in Enzyme Regulation, 2006
- Monomethylarsonous acid induces transformation of human bladder cellsToxicology and Applied Pharmacology, 2006
- Ras signaling in prostate cancer progressionJournal of Cellular Biochemistry, 2003
- A review of the source, behaviour and distribution of arsenic in natural watersApplied Geochemistry, 2002
- Androgen Receptor Mutations in Carcinoma of the ProstateAmerican Journal of PharmacoGenomics, 2001
- Cancer incidence and high environmental arsenic concentrations in rural populations: Results of an ecological studyInternational Journal of Environmental Health Research, 1999
- Mortality for Certain Diseases in Areas with High Levels of Arsenic in Drinking WaterArchives of environmental health, 1999