Intracellular Signaling MAPK Pathway After Cerebral Ischemia–Reperfusion Injury
- 20 March 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neurochemical Research
- Vol. 37 (7), 1568-1577
- https://doi.org/10.1007/s11064-012-0752-y
Abstract
The MAPK/ERK/p38 are signal transduction pathways that couple intracellular responses to the external stimuli. Contrary to ERK protein which is part of the survival route, presence of p38 could have an impact on cell injury. Tolerance induced by ischemic preconditioning (IPC) is a phenomenon of tissue adaptation, which results in increased tolerance to lethal ischemia–reperfusion injury (IRI). Paper describes changes in MAPK protein pathways after brain IPC. Ischemia was induced by 4-vessels occlusion and rats were preconditioned by sub-lethal ischemia. Western blot and immunohistochemistry identified ERK/p38 proteins in injured areas. The highest level of the pERK was detected at 24 h in IPC groups. A contrary pattern of MAPK/p38 activation was observed in this group, where the lowest level of p38 was displayed at 24 h after ischemia. This suggests that the MAPK signal transduction might have a potential role in tissues response subjected to IRI and in the phenomenon of tolerance.Keywords
This publication has 45 references indexed in Scilit:
- Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice culturesEuropean Journal of Neuroscience, 2011
- Phosphorylated Extracellular Signal-Regulated Kinase 1/2 Immunoreactivity and Its Protein Levels in the Gerbil Hippocampus during Normal AgingMolecules and Cells, 2010
- Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantationJournal of Inflammation, 2010
- Alterations Induced by Ischemic Preconditioning on Secretory Pathways Ca2+-ATPase (SPCA) Gene Expression and Oxidative Damage After Global Cerebral Ischemia/Reperfusion in RatsCellular and Molecular Neurobiology, 2009
- Molecular Mechanisms Leading to Neuroprotection/Ischemic Tolerance: Effect of Preconditioning on the Stress Reaction of Endoplasmic ReticulumCellular and Molecular Neurobiology, 2009
- Molecular Analysis of Endoplasmic Reticulum Stress Response After Global Forebrain Ischemia/Reperfusion in Rats: Effect of Neuroprotectant SimvastatinCellular and Molecular Neurobiology, 2008
- Cell type-specific activation of p38 MAPK in the brain regions of hypoxic preconditioned miceNeurochemistry International, 2007
- Time Course of Peripheral Oxidative Stress as Consequence of Global Ischaemic Brain Injury in RatsCellular and Molecular Neurobiology, 2007
- Cerebral preconditioning and ischaemic toleranceNature Reviews Neuroscience, 2006
- Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusionApoptosis, 2006