Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury
Open Access
- 17 February 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Neuroinflammation
- Vol. 10 (1), 27
- https://doi.org/10.1186/1742-2094-10-27
Abstract
Intracerebral hemorrhage (ICH) is a common type of fatal stroke, accounting for about 15% to 20% of all strokes. Hemorrhagic strokes are associated with high mortality and morbidity, and increasing evidence shows that innate immune responses and inflammatory injury play a critical role in ICH-induced neurological deficits. However, the signaling pathways involved in ICH-induced inflammatory responses remain elusive. Toll-like receptor 4 (TLR4) belongs to a large family of pattern recognition receptors that play a key role in innate immunity and inflammatory responses. In this review, we summarize recent findings concerning the involvement of TLR4 signaling in ICH-induced inflammation and brain injury. We discuss the key mechanisms associated with TLR4 signaling in ICH and explore the potential for therapeutic intervention by targeting TLR4 signaling.This publication has 115 references indexed in Scilit:
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