Pathogenicity of Live, Attenuated SIV After Mucosal Infection of Neonatal Macaques
- 24 March 1995
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 267 (5205), 1820-1825
- https://doi.org/10.1126/science.7892606
Abstract
Adult macaques do not develop disease after infection with a nef deletion mutant of the simian immunodeficiency virus (SIV) and are protected against challenge with pathogenic virus. This finding led to the proposal to use nef-deleted viruses as live, attenuated vaccines to prevent human acquired immunodeficiency syndrome (AIDS). In contrast, neonatal macaques developed persistently high levels of viremia after oral exposure to and SIV nef, vpr, and negative regulatory element (NRE) deletion mutant. Severe hemolytic anemia, thrombocytopenia, and CD4+ T cell depletion were observed, indicating that neither nef nor vpr determine pathogenicity in neonates. Because such constructs have retained their pathogenic potential, they should not be used as candidate live, attenuated virus vaccines against human AIDS.Keywords
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