Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids
- 24 July 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 4 (10), 3906-3911
- https://doi.org/10.1039/c3sc51747k
Abstract
A palladium-catalyzed alkylation of primary and secondary C(sp3)–H bonds with alkyl iodides and/or bromides for the synthesis of optically active unnatural α-amino acids (α-AAs) is described. This process is scalable and tolerates a variety of functional groups with complete retention of chirality, providing an efficient new strategy for the synthesis of various unnatural α-amino acid derivatives.Keywords
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