Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy
Open Access
- 14 December 1989
- journal article
- case report
- Published by Wiley in Arthritis & Rheumatism
- Vol. 32 (12), 1592-1596
- https://doi.org/10.1002/anr.1780321214
Abstract
Retrospective analysis of 23 rheumatoid arthritis patients receiving low‐dose methotrexate (MTX) demonstrated an association between the mean corpuscular volume (MCV) and hematologic toxicity. All 6 patients who developed hematologic toxicity were folate deficient, and 4 of 6 had marked macrocytosis. Furthermore, the mean MCV of the patients who developed toxicity was significantly higher than that of the controls without toxicity (P < 0.02). This difference in MCV was associated with an increased probability of developing toxicity with time (P < 0.005). These results suggest that sustained elevation in the MCV may be a predictor of impending hematologic toxicity due to folate depletion.Keywords
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