2-Alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)benzimidazoles: potential angiotensin II receptor antagonists
- 27 March 2000
- journal article
- research article
- Published by Elsevier BV in Tetrahedron Letters
- Vol. 41 (13), 2265-2267
- https://doi.org/10.1016/s0040-4039(00)00148-9
Abstract
2-Alkyl-1-(bromodifluoromethyl)benzimidazoles were synthesized and condensed with aromatic aldehydes to give 2-alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)-benzimidazoles. A potential nonpeptide antagonist of the angiotensin II receptor with the -CF 2 CH(OH)-bridge between the heterocyclic nitrogen atom and the biphenyl moiety was synthesized.Keywords
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