Development of an IgG4-RD Responder Index
Open Access
- 24 April 2012
- journal article
- research article
- Published by Hindawi Limited in International Journal of Rheumatology
- Vol. 2012, 1-7
- https://doi.org/10.1155/2012/259408
Abstract
IgG4-related disease (IgG4-RD) is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are required to clarify the natural history, long-term prognosis, and treatment approaches in this recently recognized condition. Patients with IgG4-RD have different organ manifestations and are followed by multiple specialties. Divergent approaches to the assessment of patients can complicate the interpretation of studies, emphasizing the critical need for validated outcome measures, particularly assessments of disease activity and response to treatment. We developed a prototype IgG4-RD Responder Index (IgG4-RD RI) based on the approach used in the development of the Birmingham Vasculitis Activity Score for Wegener’s granulomatosis (BVAS/WG). The IgG4-RD RI was refined by members of the International IgG4-RD Symposium Organizing Committee in a paper case exercise. The revised instrument was applied retrospectively to fifteen IgG4-RD patients at our institution. Those scores were compared to physician’s global assessment scale for the same visits. This paper describes the philosophy and goals of the IgG4-RD RI, the steps in the development of this instrument to date, and future plans for validation of this instrument as an outcome measure.Keywords
This publication has 12 references indexed in Scilit:
- Recommendations for the nomenclature of IgG4‐related disease and its individual organ system manifestationsArthritis & Rheumatism, 2012
- Rituximab for the Treatment of IgG4-Related DiseaseMedicine, 2012
- A clinical overview of IgG4-related systemic diseaseCurrent Opinion in Rheumatology, 2011
- Serial Changes of Elevated Serum IgG4 Levels in IgG4-related Systemic DiseaseInternal Medicine, 2011
- Treatment approaches to IgG4-related systemic diseaseCurrent Opinion in Rheumatology, 2011
- Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4‐related systemic diseaseArthritis & Rheumatism, 2010
- Novel evidence‐based systemic lupus erythematosus responder indexArthritis Care & Research, 2009
- Comparison of disease activity measures for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitisAnnals Of The Rheumatic Diseases, 2008
- The future of damage assessment in vasculitis.2007
- A disease-specific activity index for Wegener's granulomatosis: Modification of the Birmingham Vasculitis Activity ScoreArthritis & Rheumatism, 2001