Optimizing the CD34 + cell dose for reduced-intensity allogeneic hematopoietic stem cell transplantation
- 1 January 2009
- journal article
- research article
- Published by Informa UK Limited in Leukemia & Lymphoma
- Vol. 50 (9), 1434-1441
- https://doi.org/10.1080/10428190903085944
Abstract
Low CD34 + cell doses increase allograft-related mortality and very high doses increase the risk of graft-versus-host disease. The optimum CD34 + cell dose remains undefined. The effect of the CD34 + cell dose based on ideal weight was analyzed in 130 patients with hematologic malignancies undergoing reduced-intensity allogeneic blood cell transplantation in the context of factors known to affect the outcome: chemosensitivity, donor age, lactate dehydrogenase (LDH), human leukocyte antigen (HLA) match, performance status, and platelet count. The survival of patients receiving >8 x 10(6)/kg CD34 + cells was not significantly different from those receiving 8) needs further confirmation.Keywords
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