Glucocorticoid‐induced hyperglycemia (糖皮质激素诱导的高血糖)
- 17 September 2013
- journal article
- review article
- Published by Wiley in Journal of Diabetes
- Vol. 6 (1), 9-20
- https://doi.org/10.1111/1753-0407.12090
Abstract
Corticosteroid‐induced hyperglycemia is a common medical problem that can lead to frequent emergency room visits, hospital admissions and prolonged hospital stay, in addition to the well known morbidity associated with hyperglycemia. However, the diagnosis and treatment of corticosteroid‐induced hyperglycemia is surprisingly undervalued by most professionals, probably because of the lack of quality studies to determine specific strategies of action. In the present review, we discuss the pathophysiology of corticosteroid‐induced hyperglycemia, focusing on diverse patterns of hyperglycemia induced by the different formulations, and provide clues for diagnosis based on the duration of treatment and the administration schedule of corticosteroids. We propose a treatment strategy based on both the pathophysiology of the process and the mechanism of action of different corticosteroids, and take into account dosing and administration timing to predict the duration of therapy. Finally, we propose treatment goals that differ slightly between the transient and continuous use of corticosteroids based on evidence from clinical practice guidelines of diabetes care both in ambulatory and hospital settings.Keywords
This publication has 91 references indexed in Scilit:
- Glucagon-Like Peptide-1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in HumansDiabetes Care, 2011
- Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes Undergoing General Surgery (RABBIT 2 Surgery)Diabetes Care, 2011
- Standards of Medical Care in Diabetes—2011Diabetes Care, 2011
- Mechanisms of glucocorticoid-induced myopathyJournal of Endocrinology, 2008
- An Afferent Vagal Nerve Pathway Links Hepatic PPARα Activation to Glucocorticoid-Induced Insulin Resistance and HypertensionCell Metabolism, 2007
- Dexamethasone-induced insulin resistance shows no gender difference in healthy humansDiabetes & Metabolism, 2004
- Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null miceNature Medicine, 2003
- NEW-ONSET DIABETES AFTER TRANSPLANTATION: 2003 INTERNATIONAL CONSENSUS GUIDELINES1Transplantation, 2003
- Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.JCI Insight, 1997
- Fat oxidation and diabetes of obesity: The Randle hypothesis revisitedMedical Hypotheses, 1990