Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation
Open Access
- 1 January 2010
- journal article
- research article
- Published by Hindawi Limited in Neurology Research International
- Vol. 2010, 1-5
- https://doi.org/10.1155/2010/671421
Abstract
Fatigue is an indispensable bioalarm to avoid exhaustive state caused by overwork or stresses. It is necessary to elucidate the neural mechanism of fatigue sensation for managing fatigue properly. We performedpositron emission tomography scans to indicate neural activations while subjects were performing 35-min fatigue-inducing task trials twice. During the positron emission tomography experiment, subjects performed advanced trail-making tests, touching the target circles in sequence located on the display of a touch-panel screen. In order to identify the brain regions associated with fatigue sensation, correlation analysis was performed using statistical parametric mapping method. The brain region exhibiting a positive correlation in activity with subjective sensation of fatigue, measured immediately after each positron emission tomography scan, was located in medial orbitofrontal cortex (Brodmann's area 10/11). Hence, the medial orbitofrontal cortex is a brain region associated with mental fatigue sensation. Our findings provide a new perspective on the neural basis of fatigue.
Keywords
Funding Information
- Japanese Ministry of Education, Culture, Sports, Science, and Technology
This publication has 22 references indexed in Scilit:
- The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndromePsychological Medicine, 2008
- Fatigue induces greater brain signal reduction during sustained than preparation phase of maximal voluntary contractionBrain Research, 2005
- Fatigue and basal gangliaJournal of the Neurological Sciences, 2000
- Emotion, Decision Making and the Orbitofrontal CortexCerebral Cortex, 2000
- Anatomic basis of cognitive-emotional interactions in the primate prefrontal cortexNeuroscience & Biobehavioral Reviews, 1995
- Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkeyJournal of Comparative Neurology, 1992
- Anatomical mapping of functional activation in stereotactic coordinate spaceNeuroImage, 1992
- Validity and reliability of a scale to assess fatiguePsychiatry Research, 1991
- A Theory of Emotion, and its Application to Understanding the Neural Basis of EmotionCognition and Emotion, 1990
- Association fiber pathways to the frontal cortex from the superior temporal region in the rhesus monkeyJournal of Comparative Neurology, 1988