Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults

Abstract
The high and sustained prevalence of obesity is among the most significant public health problems for the 21st century.1 Rates of severe obesity have increased even faster during the past 3 decades,2,3 particularly among African American women.1 This has clinically important implications because of the increased prevalence of comorbid conditions, especially hypertension and type 2 diabetes mellitus,4,5 among persons with severe obesity.