Severely impaired cerebrovascular reserve in patients with cerebral proliferative angiopathy
- 1 September 2011
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery: Pediatrics
- Vol. 8 (3), 310-315
- https://doi.org/10.3171/2011.6.peds1170
Abstract
Object Cerebral proliferative angiopathy (CPA) has been morphologically distinguished from classically appearing brain arteriovenous malformations (AVMs) by exhibition of functional brain parenchyma that is intermingled with abnormal vascular channels. The presence of oligemia in this intralesional brain tissue may suggest ischemia, which is not detected in classic brain AVMs. The authors hypothesized that patients with CPA would exhibit a greater impairment of cerebrovascular reserve in neuronal tissue surrounding the true nidus compared with those with brain AVMs. Methods Four patients with CPA, 10 patients with brain AVMs and seizures, and 12 young healthy individuals were studied. The 4 patients with CPA underwent blood oxygen level–dependent MR imaging examinations while applying normoxic step changes in end-tidal CO2 to obtain quantitative cerebrovascular reactivity measurements. Results Patients with a CPA lesion exhibited severely impaired perilesional cerebrovascular reserve in comparison with pa...This publication has 18 references indexed in Scilit:
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