Recent Knowledge of the Relationship Between Helicobacter pylori and Gastric Cancer and Recent Progress of Gastroendoscopic Diagnosis and Treatment for Gastric Cancer
Open Access
- 23 August 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in Japanese Journal of Clinical Oncology
- Vol. 40 (9), 828-837
- https://doi.org/10.1093/jjco/hyq119
Abstract
Gastric cancer is a multi-step process and multi-factorial disease. However, Helicobacter pylori plays the most important role in gastric carcinogenesis because most gastric cancers including both intestinal type and diffuse type arise from mucosa infected by H. pylori. The relationship between H. pylori infection and gastric cancer has been proved in epidemiological studies, animal experiments with Mongolian gerbils, and clinical prospective studies. Significant preventive effect of H. pylori eradication was reported in Japanese randomized study for secondary gastric cancer after endoscopic resection of primary gastric cancer and meta-analysis of randomized studies. The Japanese Society for Helicobacter Research has published a guideline recommending that H. pylori infection should be treated by eradication therapy to suppress the incidence of gastric cancer. The development of endoscopic technology has advanced the diagnosis and treatment of gastric cancer. In the diagnosis of gastric cancer, image enhancement endoscopy including magnifying observation with narrow-band imaging system and microscopic magnifying observation opens the possibility of optical biopsy. Endoscopic resection for early stage of gastric cancer has been established as proper treatment of early gastric cancer. Recently endoscopic submucosal dissection had made en bloc resection possible for mucosal cancers >2 cm in diameter. Because of endoscopic submucosal dissection, endoscopic resection is indicated in a greater number of cases. Although the use of endoscopic treatment for gastric cancer has been increasing steadily, long-term outcome data is necessary.Keywords
This publication has 64 references indexed in Scilit:
- Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trialThe Lancet, 2008
- Baseline gastric mucosal atrophy is a risk factor associated with the development of gastric cancer after Helicobacter pylori eradication therapy in patients with peptic ulcer diseasesThe Esophagus, 2007
- Inflammatory bowel disease: past, present, and futureThe Esophagus, 2007
- Endoscopic mucosal resectionGastrointestinal Endoscopy, 2003
- Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronateGastrointestinal Endoscopy, 2002
- Gastric cancer treatment guidelines in JapanGastric Cancer, 2002
- Helicobacter pyloriInfection and the Development of Gastric CancerThe New England Journal of Medicine, 2001
- A novel method of endoscopic mucosal resection using sodium hyaluronateGastrointestinal Endoscopy, 1999
- Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pyloriThe Lancet, 1993
- Endoscopic mucosal resection with a cap-fitted panendoscope for esophagus, stomach, and colon mucosal lesionsGastrointestinal Endoscopy, 1993