Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
- 1 May 2012
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry
- Vol. 20 (9), 3031-3037
- https://doi.org/10.1016/j.bmc.2012.03.002
Abstract
No abstract availableKeywords
Funding Information
- The National Cancer Institute (1R01CA120009, 3R01CA120009-04S1, 5R01CA127258-05)
This publication has 57 references indexed in Scilit:
- Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogsBioorganic & Medicinal Chemistry, 2009
- Antitumor activity of novel fluoro-substituted (–)-epigallocatechin-3-gallate analogsCancer Letters, 2009
- Natural products in drug discoveryDrug Discovery Today, 2008
- AMPK Phosphorylation of Raptor Mediates a Metabolic CheckpointMolecular Cell, 2008
- ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical OutcomeCell Stem Cell, 2007
- Structural basis for AMP binding to mammalian AMP-activated protein kinaseNature, 2007
- Synthesis of (2R,3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activitiesTetrahedron, 2007
- A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducerBioorganic & Medicinal Chemistry, 2007
- Post-translational modification of p53 in tumorigenesisNature Reviews Cancer, 2004
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseNature, 2002