Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity disorder
Open Access
- 12 September 2006
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 63 (3), 371-375
- https://doi.org/10.1111/j.1365-2125.2006.02767.x
Abstract
To investigate dexamphetamine transfer into milk, infant doses and effects in the breast-fed infant. Four women taking dexamphetamine, and their infants were studied. The median maternal dexamphetamine dose was 18 mg day(-1) (range 15-45 mg day(-1)). Median (interquartile range) descriptors were 3.3 (2.2-4.8) for milk/plasma ratio, 21 microg kg(-1) day(-1) (11-39) for absolute infant dose and 5.7% (4-10.6%) for relative infant dose. No adverse effects were seen. In three infants tested, dexamphetamine in plasma was undetected in one (limit of detection 1 microg l(-1)) and present at 18 microg l(-1) and 2 microg l(-1) in the other two. Dexamphetamine readily transfers into milk. The relative infant dose was <10% and within a range that is generally accepted as being 'safe' in the short term.Keywords
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