Prospects for Tuberculosis Elimination
Top Cited Papers
- 18 March 2013
- journal article
- review article
- Published by Annual Reviews in Annual Review of Public Health
- Vol. 34 (1), 271-286
- https://doi.org/10.1146/annurev-publhealth-031912-114431
Abstract
The target for TB elimination is to reduce annual incidence to less than one case per million population by 2050. Meeting that target requires a 1,000-fold reduction in incidence in little more than 35 years. This can be achieved only by combining the effective treatment of active TB—early case detection and high cure rates to interrupt transmission—with methods to prevent new infections and to neutralize existing latent infections. Vigorous implementation of the WHO Stop TB Strategy is needed to achieve the former, facilitated by the effective supply of, and demand for, health services. The latter calls for new technology, including biomarkers of TB risk, diagnostics, drugs, and vaccines. An important milestone en route to elimination will be reached when there is less than 1 TB death per 100,000 population, marking entry into the elimination phase. This landmark can be reached by many countries within 1–2 decades.Keywords
This publication has 41 references indexed in Scilit:
- Which New Diagnostics for Tuberculosis, and When?The Journal of Infectious Diseases, 2012
- Practical Preventive Therapy for Tuberculosis?The New England Journal of Medicine, 2011
- A multistage tuberculosis vaccine that confers efficient protection before and after exposureNature Medicine, 2011
- The construction of next-generation matrices for compartmental epidemic modelsJournal of The Royal Society Interface, 2009
- The spectrum of latent tuberculosis: rethinking the biology and intervention strategiesNature Reviews Microbiology, 2009
- A Dynamic Reinfection Hypothesis of Latent Tuberculosis InfectionInfection, 2009
- Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatmentThe Lancet, 2006
- Health system frailties in tuberculosis service provision in Russia: an analysis through the lens of formal nutritional supportPublic Health, 2005
- The effect of tuberculosis control in ChinaThe Lancet, 2004
- Prospects for worldwide tuberculosis control under the WHO DOTS strategyThe Lancet, 1998