Structural and functional insights into core ABA signaling
- 9 October 2010
- journal article
- review article
- Published by Elsevier BV in Current Opinion in Plant Biology
- Vol. 13 (5), 495-502
- https://doi.org/10.1016/j.pbi.2010.09.007
Abstract
A series of papers in the last year reported major advances in our understanding of abscisic acid (ABA) signaling: the identification of soluble ABA receptors, the elucidation of a core ABA signaling pathway and structural insights into the mechanism of ABA perception and signaling. Here we summarize these advances, which have shown in atomic resolution that the ABA receptors PYR1, PYL1 and PYL2 function as allosteric switches that inhibit type 2C protein phosphatases (PP2Cs) in response to ABA. These receptors function at the apex of a core signaling pathway that regulates ABA responses by controlling SnRK2 kinase activity and the phosphorylation of downstream target proteins such as ABFs, which control nuclear responses, and the ion channel SLAC1, which mediates electrophysiological responses to ABA.Keywords
This publication has 51 references indexed in Scilit:
- Guard cell anion channel SLAC1 is regulated by CDPK protein kinases with distinct Ca 2+ affinitiesProceedings of the National Academy of Sciences of the United States of America, 2010
- Plant PP2C phosphatases: emerging functions in stress signalingTrends in Plant Science, 2004
- Arabidopsis OST1 Protein Kinase Mediates the Regulation of Stomatal Aperture by Abscisic Acid and Acts Upstream of Reactive Oxygen Species ProductionPlant Cell, 2002
- The Abscisic Acid-Responsive Kinase PKABA1 Interacts with a Seed-Specific Abscisic Acid Response Element-Binding Factor, TaABF, and Phosphorylates TaABF Peptide SequencesPlant Physiology, 2002
- Abscisic Acid Signaling in Seeds and SeedlingsPlant Cell, 2002
- Hyperosmotic Stress Induces the Rapid Phosphorylation of a Soybean Phosphatidylinositol Transfer Protein Homolog through Activation of the Protein Kinases SPK1 and SPK2Plant Cell, 2001
- Adaptations of the helix-grip fold for ligand binding and catalysis in the START domain superfamilyProteins-Structure Function and Bioinformatics, 2001
- Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditionsProceedings of the National Academy of Sciences of the United States of America, 2000
- Regulation of Abscisic Acid-Induced Stomatal Closure and Anion Channels by Guard Cell AAPK KinaseScience, 2000
- Osmotic stress induces rapid activation of a salicylic acid-induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells.2000