Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology
- 1 September 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Behavioural Pharmacology
- Vol. 18 (5-6), 521-531
- https://doi.org/10.1097/fbp.0b013e3282d28f83
Abstract
Chronic fluoxetine increases neurogenesis in the dentate gyrus (DG). In view of the widespread clinical use of fluoxetine and the well-established role of the DG in memory, surprisingly few studies have examined the effects of fluoxetine on memory and hippocampal electrophysiology. Additionally, few studies have evaluated the potential for fluoxetine to promote recovery of function after DG damage. Therefore, we studied the effects of long-term administration of fluoxetine on both spatial-reference memory and working memory, recovery of function after intrahippocampal colchicine infusions, which can destroy 50–70% of DG granule cells, and electrophysiological responses in the DG to perforant path stimulation in freely moving rats. Chronic fluoxetine did not affect matching-to-place or reference-memory performance in intact rats in the Morris water-maze task. Surprisingly, in rats with DG damage, recovery of function on both tasks was adversely affected by chronic fluoxetine. Finally, unlike an earlier study that reported fluoxetine-induced increases in hippocampal population spike amplitudes and excitatory postsynaptic potential slopes in urethane-anesthetized rats, electrophysiological measures in DG of freely moving rats were not affected by chronic fluoxetine treatment.Keywords
This publication has 40 references indexed in Scilit:
- Adrenalectomy‐induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetineHippocampus, 2006
- Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factorBehavioural Brain Research, 2005
- Chlordiazepoxide interactions with scopolamine and dizocilpine: Novel cooperative and antagonistic effects on spatial learning.Behavioral Neuroscience, 2005
- A Transgenic Marker for Newly Born Granule Cells in Dentate GyrusJournal of Neuroscience, 2004
- Effects of positive GABAA modulators on a multiple-component, repeated-acquisition test of spatial learningBehavioural Pharmacology, 2003
- Repeated spatial acquisition: Effects of NMDA antagonists and morphine.Experimental and Clinical Psychopharmacology, 2003
- The Anesthetic Mechanism of Urethane: The Effects on Neurotransmitter-Gated Ion ChannelsAnesthesia & Analgesia, 2002
- Ultrastructural localization of 5-hydroxytryptamine1A receptors in the rat brainJournal of Neuroscience Research, 1996
- Comparison of long-term enhancement and short-term exploratory modulation of perforant path synaptic transmissionBrain Research, 1993
- Comparison of the neurotoxic effects of colchicine, the vinca alkaloids, and other microtubule poisonsBrain Research, 1989