Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
Open Access
- 6 June 2016
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 17 (8), 966-975
- https://doi.org/10.1038/ni.3483
Abstract
Nikolich-Žugich and colleagues describe a unique subset of human T cells with a naive phenotype and the ability to rapidly produce cytokines in response to engagement of the T cell antigen receptor. The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8+ T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8+ T cells, called 'memory T cells with a naive phenotype' (TMNP cells), increased with age and after severe acute infection and inversely correlated with the residual capacity of the immune system to respond to new infections with age. CD8+ TMNP cells represent a potential new target for the immunotherapy of persistent infections and should be accounted for and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.Keywords
This publication has 51 references indexed in Scilit:
- TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusionsGenome Biology, 2013
- Standardizing immunophenotyping for the Human Immunology ProjectNature Reviews Immunology, 2012
- Extracting a cellular hierarchy from high-dimensional cytometry data with SPADENature Biotechnology, 2011
- A human memory T cell subset with stem cell–like propertiesNature Medicine, 2011
- A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic ChemotherapyImmunity, 2009
- Adoptively transferred effector cells derived from naïve rather than central memory CD8 + T cells mediate superior antitumor immunityProceedings of the National Academy of Sciences of the United States of America, 2009
- Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusNature Immunology, 2009
- Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humansThe Journal of Experimental Medicine, 2008
- Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primatesProceedings of the National Academy of Sciences of the United States of America, 2007
- Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response MagnitudeImmunity, 2007