Evaluation of Genetic Susceptibility Loci for Obesity in Chinese Women
Open Access
- 8 July 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 172 (3), 244-254
- https://doi.org/10.1093/aje/kwq129
Abstract
Recent genome-wide association (GWA) studies have identified 18 genetic loci for obesity. Using directly observed and imputed GWA genotyping data on approximately 5,000 Chinese women (1996–2007), the authors evaluated 17 single nucleotide polymorphisms (SNPs) that represent 17 distinct obesity loci. Two SNPs near the BAT2 and MC4R genes and 3 SNPs within the FTO, SEC16B, and SH2B1 genes were significantly associated with body mass index (weight (kg)/height (m)2), body weight, and the prevalence of obesity. The per-allele increase in body mass index ranged from 0.16 units (BAT2) to 0.38 units (SH2B1). Odds ratios for obesity ranged from 1.46 (95% confidence interval (CI): 1.12, 1.92) for BAT2 to 2.16 (95% CI: 1.39, 3.37) for MC4R. A genetic risk score calculated by summing the number of risk-increasing alleles that each woman carried at these 5 loci was significantly associated with the prevalence of obesity. Women carrying 5 or more risk alleles had a 3.13-fold (95% CI: 2.06, 4.77) higher prevalence of obesity than women carrying 1 or no risk alleles. Results from this study extend some previous GWA findings to Chinese women and show the need for additional studies to identify susceptibility loci in Chinese and other Asian populations.Keywords
This publication has 57 references indexed in Scilit:
- A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traitsNature Genetics, 2009
- Overweight and Obesity: Prevalence, Consequences, and Causes of a Growing Public Health ProblemThe American Journal of the Medical Sciences, 2006
- The Human Obesity Gene Map: The 2005 UpdateObesity, 2006
- Divergence of Melanocortin Pathways in the Control of Food Intake and Energy ExpenditureCell, 2005
- The Shanghai Women's Health Study: Rationale, Study Design, and Baseline CharacteristicsAmerican Journal of Epidemiology, 2005
- ObesityThe Lancet, 2005
- Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in miceCell Metabolism, 2005
- Obesity: The worldwide epidemicClinics in Dermatology, 2004
- Genetics of body-weight regulationNature, 2000
- Genetic and Environmental Factors in Relative Body Weight and Human AdiposityBehavior Genetics, 1997